ccRCC, which originates from the epithelial cells of the proximal tubules in the kidney and accounts for approximately 75% of RCC cases, is characterized by von Hippel–Lindau tumor suppressor (VHL) gene mutations, high angiogenesis, and significant metabolic reprogramming, making it the most aggressive subtype [3]. This evidence concerns the gene VHL and nonpapillary renal cell carcinoma.