The core scaffold in Nutlins is cis-imidazoline, which structurally incorporates phenyl ring functional groups that resemble the three key residues of p53: Phe19, Trp23 and Leu26 This enables them to specifically interfere with the interaction between MDM2 and p53, promoting p53 protein accumulation and activation, thereby inducing apoptosis and exerting anti-tumor effects [41]. The gene discussed is TP53; the disease is neoplasm.