LINC00458 and heart disorder: Several lncRNAs have been reported to play pivotal roles during cardiogenesis, such as HBL1 [98,99], Linc1405 [100], CARMA [101], Moshe [102] and Braveheart [49], during cardiac diseases such as Sweetheart [103], lncExACT1 [104] and Malat1 [105] as well as promoting cardiac regeneration such as CAREL [106] and Snhg1 [107] [for a recent review, see [108]].