All these markers have specific characteristics and belong to different categories: Aβ42/40 ratio reflects “A” (Aβ proteinopathy, Core 1 biomarkers), p-tau isoforms 181, 217 and 231 reflect “T1” (phosphorylated and secreted AD tau, Core 1 biomarkers), NfL reflects “N” (injury, dysfunction, or degeneration of neuropil), GFAP reflects “I” (inflammation) [5]. The gene discussed is MAPT; the disease is Alzheimer disease.