PIK3R1 and breast cancer: To gain further insight into the possible functional consequences of BC-induced changes in the hepatic miRNAs, we assessed the liver mRNA levels of reported miR-122 target genes (Klf6, Vegf), miR-122 modulators (Rora), the Pik3r1 gene that was highlighted in our bioinformatic analyses, and the Bco1 gene (Figure 9B).