Though the principal component analysis (PCA) showed no clear separation between the groups (Figure S1A), the analysis of the differentially expressed genes (DEGs) revealed 52 downregulated genes and 80 upregulated genes in samples from the USP8-mutant tumors (Figure S1B; the whole list of DEGs associated with USP8 mutations in adenomas is given in Supplementary Table S3). The gene discussed is USP8; the disease is adenoma.