VEGFA and neoplasm: This process releases growth factors such as VEGF and fibroblast growth factors (FGFs) binding to receptors on the cell surface, activating integrin signaling pathways and enhancing the adhesion and migration capabilities of tumor cells, which further influence the activity of the Hippo pathway, resulting in the accumulation of YAP/TAZ in the nucleus and the regulation of gene expression associated with tumor growth and invasion [141,143].