CCN2 and cancer: This interaction stabilizes the structure of TEAD and significantly enhances its transcriptional activity [50], which leads to the upregulation of genes associated with cell proliferation, migration, and survival, including connective tissue growth factor (CTGF), cysteine-rich angiogenic inducer 61 (CYR61), and annexin A2 (ANX2) helping cells to respond to external signals, maintain tissue homeostasis, and is closely related to various pathological conditions, such as fibrosis and cancer [51].