In another animal model analyzing the effect of the FXR agonist cilofexor on NASH fibrotic rats, a decrease in portal pressure without changes in splanchnic blood flow or systemic hemodynamics occurred after the addition of propranolol; while cilofexor seems to primarily decrease sinusoidal resistance in cirrhotic portal hypertension, the combination of the two drugs reduced splanchnic inflow, but also the mean arterial pressure and heart rate [157]. Here, NR1H4 is linked to portal hypertension.