Notably, neutrophils appear to be involved in congestive liver disease progression; the increase in shear stress can interact with mechanosensitive calcium channels that increase the expression of chemokine (C-X-C motif) ligand 1 (CXCL1), a neutrophil chemoattractant, which promotes the formation of neutrophil extracellular traps (NETs) involved in microvascular thrombosis and the progression of liver injury and portal hypertension [76]. This evidence concerns the gene CXCL1 and portal hypertension.