SOD2 and Parkinson disease: The above is consistent with the data collected in a mouse model of PD, which show that PGC-1α overexpression in dopaminergic neurons protects against MPTP neurotoxin-induced cell degeneration due to the increased expression of the mitochondrial antioxidants Superoxide dismutase-2 (SOD2) and Thioredoxin-2 (Trx2) [79].