MFN2 and Alzheimer disease: Djordjevic et al. [62] investigated the expression of Drp1 and Mfn2 proteins in hippocampal and cortical neurons in the AD model of 3xTg transgenic mice and showed a decrease in the level of Mfn2 protein accompanied by an increase in the level of Drp1 in the cortex of female and male 6-month-old 3xTg mice compared to the control.