MAPT and early-onset autosomal dominant Alzheimer disease: A number of other studies have also demonstrated a link between the Drp1 protein and the progression of Alzheimer’s disease [34,64]: the interaction between Drp1 and the accumulation of AD toxic proteins Aβ and tau enhances the activity of Drp1, which leads to an excessive predominance of the mitochondrial fission [65,66].