DNM1L and Mental deterioration: According to Zhou et al., the phosphorylation of Drp1 at S616 activates Drp1, promotes mitochondrial translocation of the protein, resulting in mitochondrial fragmentation, and is possibly involved in neuronal death [35], suggesting that the increased level of phospho-Drp1 correlates with the mitochondrial morphological changes in the hippocampus and cognitive decline observed with aging.