DPP4 and inflammatory bowel disease: Further research focused on revealing the cellular dynamics of DPP4 release and shedding, investigating the interplay between microbiota-derived and host DPP4-like activity in translational models, and exploring patient-specific microbiome profiles to inform personalized therapeutic approaches is demanded to elucidate the underlying mechanisms driving DPP4-gut microbiome interactions and validate the therapeutic efficacy of targeting these pathways in the management of IBD and other IMIDs.