For example, combining an anti-CD73 mAb with chemo-photodynamic therapy has demonstrated enhanced antimetastatic effects in animal models of triple-negative breast cancer by boosting T-cell-mediated immunity while preventing abscopal effect [146], involved in tumor metastasis [147] by inducing systemic cytotoxic T-cell response via CD73 blockade [146]. The gene discussed is NT5E; the disease is triple-negative breast carcinoma.