In this study, we conducted a KEGG enrichment analysis on the DEGs from the Con_vs_AD comparison group and found that the significantly enriched signaling pathways related to signal transduction mainly include cytokine–cytokine receptor interactions, IL-17, NOD-like receptors, chemokines, Toll-like receptors, Staphylococcus aureus infection, NF-κB, TNF, and JAK-STAT signaling pathways. Here, NFKB1 is linked to staphylococcus aureus infection.