In T-ALL, the Notch signaling pathway influences Bcl-2 regulation; specifically, Notch hyperactivation leads to the transcriptional upregulation of several anti-apoptotic proteins, including Bcl-2, Bcl-xL, and Mcl1, while down regulating effector proteins such as BAX and BAK. This evidence concerns the gene MCL1 and acute lymphoblastic leukemia.