SOCS3 and Insulin resistance: Lastly, it was shown in a mice study that the higher abundance of Bacteroides (Bacteroidetes phyla), Parabacteroides (Bacteroidetes phyla), and Bilophila (Proteobacteria phyla) is positively correlated with hepatic miRNA-5112, which regulates genes that could contribute to insulin resistance, such as Akt1, Socs3, potassium calcium-activated channel subfamily N member 1(Kcnn1), L-selectin mediated binding receptor domain containing 1(Lmbrd1), and growth factor receptor-bound protein 10 (Grb10) [89].