IFNG and Alzheimer disease: Figure 4C shows enriched graph patterns generated from GSEA, illustrating the suppression of mitochondrial complex I activity and mitochondrial translation processes in the brain. Additionally, in Supplementary Figure S1, the 50 hallmark gene set analysis revealed that the most significantly altered gene sets due to a HFD were those associated with IFN-γ and IFN-α in App (NL-F/NL-F) mice, a mouse model of AD.