CXCL8 and infection: Also, interleukins like IL-2, IL-6, IL-8, and IL-12 are significant modulators of the immune system: IL-2 promotes T-cell proliferation, IL-6 acts as a pro-inflammatory cytokine, IL-8 recruits neutrophils to infection sites, and IL-12 enhances the differentiation of T-helper cells [29,30,31,32].