CD4 and psoriasis: Figure 4a depicts the maternal network, in which NTRK1 is not directly connected to the atopy node but is involved in cell differentiation. Previous studies have indicated that NTRK1 is upregulated in allergic inflammatory tissues [42]. In Figure 4b, the infant network reveals the downregulation of TIGIT, which inhibits CD4 T cell responses and has also been shown to be downregulated in psoriasis, according to prior research [41]. Additionally, IL31RA was upregulated, confirming that the results for these two nodes are consistent with previous findings [38].