SLC7A11 and hyperinsulinemic hypoglycemia, familial, 4: Specifically, SLC7A11 deficiency accelerated MASLD progression via a classic cystine/cysteine deficiency-induced ferroptosis, while serine deficiency and a resulting impairment in de novo cysteine production were attributed to ferroptosis-induced MASLD progression in mice overexpressing hepatic SLC7A11 [182].