CCND1 and melanoma: Apart from melanoma, curcumin effectively modulates the WNT/β-catenin pathway in breast cancer, as it inhibited proliferation and induced the apoptosis of breast cancer cells through the inhibition of DVL, β-catenin and cyclin D1 [111], as well as through the downregulation of phospho-GSK3β and β-catenin [112].