AXIN2 and melanoma: It has been found that quercetin induced apoptosis in melanoma cells and destabilized the WNT-FZD-LRP6 complex by suppressing DVL2 and AXIN2, which resulted in decreased β-catenin and the inhibition of the WNT-responsive gene encoding cyclin D1 (CCND1) and cyclooxygenase (COX2).