NFKB1 and Premature ovarian insufficiency: Moreover, in a rodent premature ovarian insufficiency model induced by chemotherapy or radiotherapy, resveratrol inhibited oxidative stress and inflammatory events in the ovaries by activating the PI3K/Akt/mTOR and NF-κB signaling pathways [47], improving loss of the oogonial stem cells through antiapoptotic effects [48].