Several studies using various animal models of depression and cognitive impairment have reported that resveratrol treatment alleviates cognitive deficits and reductions in BDNF and pCREB/CREB levels, likely through the modulation of neuroinflammation [87,88] and the activation of the Sirt1/miR-134 pathway [89]. The gene discussed is CREB1; the disease is depressive symptom measurement.