These miRNAs also target the glutathione transferase P1 (GSTP1), an enzyme involved in detoxification and a potential biomarker of myocardial stress and heart failure [66,67], and the hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) channel, a transmembrane protein which regulates heart rate [68]. Here, HCN4 is linked to heart failure.