IGHE and allergic disease: The microRNAs and pulmonary genes, such as PON1, Bex2, Igfbp6, and Scgb1c1, by ASC-derived EVs induce the expansion of Tregs secreting IL-10 and TGF-β, which leads to a decrease in allergy-specific Th2 cytokines (IL-4, IL-5, and IL-13), pulmonary eosinophil infiltration, allergy-specific IgG1 and IgE production, and AHR in asthmatic mice [9,32].