PTEN and endometrial cancer: In ovarian and endometrial cancers, ARID1A mutations often co-occur with alterations in the PI3K/AKT (phosphoinositide 3-kinase/activated protein kinase) pathway genes KRAS (Kirsten rat sarcoma virus), PIK3CA, and PTEN (phosphatase and tensin homolog) [8,13,15,94,96,102,104,105].