Studies have shown that the expression of proteins in the MAPK pathway is significantly increased in IBD, and natural products such as quercetin and olive [70,83] inhibit the MAPK pathway in mice induced by DSS, thereby suppressing the expression of pro-inflammatory factors such as tumor necrosis factor α (TNF-α), IL-1β, and IL-6. The gene discussed is TNF; the disease is inflammatory bowel disease.