DTNBP1 and schizophrenia: Given that NET is the major mechanism controlling dopamine reuptake in the PFC and, therefore, critical for regulating basal dopamine content [58], an important step in future work should be a more thorough characterization of how the dysbindin-1 mutation influences noradrenergic transmission within the PFC of relevance to its role in the cognitive symptomology of schizophrenia [59,60].