WNK2 and neoplasm: M3G has already been reported for its excellent bioactivities, including the amelioration of oxidative stress, the inhibition of lipid peroxidation in mouse brain homogenates [52], the inhibition of tumor cell growth in the human cell line A-431, and vascular endothelial growth factor (VEGF)-induced angiogenesis [53] in RGC-5 cells by hindering the cAMP pathway, epidermal growth factor receptor (EGFR), and mitogen-activated protein kinase (MAPK) signaling pathway, which is required for normal cell growth and differentiation [54].