IPA analysis of ARF-8 EVs (Figure 3) found associated molecules and pathways involving TGFB, and FunRich implied that epithelial-to-mesenchymal transition (EMT) pathways may exist, as might be expected for a migratory/metastatic cancer expressing beta-catenin and a Wnt family member [30,31] along with TGFB and numerous integrins. Here, TGFB1 is linked to metastatic malignant neoplasm.