Collectively, the current literature strongly suggests a role for PL-MSCs in positive vascular remodeling mainly by modulating Wnt signaling, secreting angiogenic factors, the upregulation of C-reactive proteins (CRP), as well as significantly reducing M1/M2 macrophage inflammations in different models of vascular injuries/limb ischemia/cardiac repair [65,66,67]. The gene discussed is CRP; the disease is limb ischemia.