In roof/epithelial (CD−M1), Myo6 and Actg1 were associated with nonsyndromic hearing loss (NSHL), Hsd17b4 with Perrault syndrome, Ednrb and Edn3 with Waardenburg syndrome, and Actg1 with Baraitser–Winter syndrome. This evidence concerns the gene EDN3 and nodular sclerosis classical Hodgkin lymphoma.