In roof/epithelial (CD−M1), Myo6 and Actg1 were associated with nonsyndromic hearing loss (NSHL), Hsd17b4 with Perrault syndrome, Ednrb and Edn3 with Waardenburg syndrome, and Actg1 with Baraitser–Winter syndrome. The gene discussed is EDN3; the disease is nonsyndromic deafness.