HDAC6 and breast cancer: Subsequently, a total of 1224 differentially expressed genes (DEGs) were distinguished across the two groups, comprising 68 upregulated and 1156 downregulated genes, as depicted in Figure 1E. The top 15 genes associated with UBA1 (R > 0.5 and p < 0.05) in BC (KDM5C, CDK16, ELK1, CCDC120, FTSJ1, ARAF, TFE3, HDAC6, PRICKLE3, SMC1A, GPKOW, NONO, HUWE1, UBQLN2, CCDC22) are also shown in Figure 1F.