ESR1 and breast lobular carcinoma: The OS results demonstrated that individuals with high UBA1 expression had notably unfavorable prognoses in several subgroups, such as T1 and T2 (p = 0.003), ductal carcinoma (p = 0.040), lobular carcinoma (p = 0.002), progesterone receptor (PR)-positive (p = 0.001), estrogen receptor (ER)-positive (p < 0.001) (Figure 5C,D).