Notably, four loci (rs11899121 [chr2p24], rs7556898 [chr2q24.3], rs17249754 [ATP2B1], and rs1980854 [chr20p12.2]) were significantly associated with hypertension in the high-METS-IR group (T3), rs10857147 (FGF5) was significant in both T1 and T3, and rs671 (ALDH2) was significant only in T1. This evidence concerns the gene FGF5 and Hypertension.