NFE2L2 and necrotizing enterocolitis: Activation of the anti-inflammatory KEAP1-NRF2 pathway by HA has been broadly reported in a number of tissues (e.g., [88]), and our functional enrichment analyses support extrapolation of these effects to HA35 within the developing neonatal ileum, implicating a role for HM HA35 in enhancing intestinal resilience, preventing oxidative damage, and mitigating risk of NEC.