One study showed that EVs obtained from Drynariae Rhizoma roots were enriched in the enzyme NAD(P)H-quinone oxidoreductase, widely distributed in eukaryotic cells and recognized for its protective mechanism against quinone-induced oxidative damage in the oxidative phosphorylation pathway [68], suggesting a protective role in oxidative stress-associated disorders such as AD, PD, and in Huntington’s disease (HD) [69]. The gene discussed is NQO1; the disease is Huntington disease.