SOD2 and chronic kidney disease: In the unique large study [5], considering a cohort of 230 patients with MN in which anti-SOD2 antibody serum levels were determined in parallel with the two major membrane-targeted autoantibodies, i.e., anti-PLA2R1 with anti-PLA2R1 epitopes and anti-THSD7A, anti-SOD2 antibodies emerged as the major factor associated with poor response to drugs and evolution to chronic renal failure.