NFE2L2 and ischemia: Finally, using a rat model of cerebral ischaemia–reperfusion injury, Zhu et al. [92] demonstrated that O3 can limit neuronal damage by reducing ferroptosis through the Nrf2/SLC7A11/GPx4 pathway, particularly by increasing the nuclear translocation of Nrf2 and the expression of SLC7A11 and GPx4.