Targeting RNS-mediated excessive autophagy/mitophagy (e.g., by inhibiting peroxynitrite) or inhibiting Kelch-like ECH-associated protein 1 (Keap1) and Keap1–Nrf2 protein–protein interactions in order to enhance the antioxidant Nrf2 pathway are other promising strategies that are currently explored in MS and other neurodegenerative disorders [412,809]. The gene discussed is NFE2L2; the disease is myeloid sarcoma.