In these B cell subsets, Foxo1 was differentially expressed, showing that Foxo1 inhibits the development of IL-10-producing B cells by suppressing Blimp-1 expression (which is essential for allergen-induced asthma and Th2 cell development in the lung) [86], and thus contributing to asthma immunopathology. Here, FOXO1 is linked to asthma.