RELA and Autoimmunity: In this context, an enrichment analysis using Biocarta indicated that the IL10 and TNF-α genes are highly correlated with NF-κB and related pathways such as RELA (Transcription Factor P65) and the HIVNEF (HIV-1 Nef-Interacting Protein), which plays a role in autoimmunity through the regulation of NF-κB [54].