CCL2 and Sepsis: It has also been recorded that deficiency of platelet GPIbα glycoprotein in mouse sepsis can result in decreased platelet–neutrophil and platelet–monocyte interactions, which reduces the synthesis of TNF-α, IL-6, and the chemokines MCP-1 (monocyte chemoattractant protein-1) (CCL-2) and MIP-1β (macrophage inflammatory protein-1β) (CCL-4), as well as other inflammatory factors [15,17,43,87,102].