Further research showed that the long-term noise stress affected the regulation of the HPA axis to cause the metabolic disorders in the body, including purine metabolism, GPL metabolism, and ether lipid metabolism, then induced changes in a variety of biological signaling pathways, and may have further induced body oxidative stress injury and the occurrence of other related diseases, such as cardiovascular and cerebrovascular diseases. This evidence concerns the gene IL31RA and Other metabolic disease.