So far, there have been many studies on ginsenosides’ antidepressive effects through the PI3K/AKT signaling pathway, while there are few studies on ginsenosides’ effects on depression through the AMPK/SIRT1 signaling pathway, so we chose the AMPK/SIRT1 signaling pathway for follow-up experimental verification. This evidence concerns the gene AKT1 and major depressive disorder.