Epigenetic events are progressively being more associated with cancer, being identified as a possible cause for the activation or silencing of certain genes depending on their biological context [16], More recently, it has been published that the downregulation of MGP in breast cancer could be due to one methylation site in the proximal region of the MGP promotor and higher levels of MGP could predict a better survival outcome [17]. This evidence concerns the gene MGP and cancer.