MGP and cancer: Of the 11 tumors queried, the MGP gene was altered in bladder (2%), breast (2%), colorectal (1%), esophageal (4%), head and neck (<1%), liver (<1%), lung (1%), and prostate (2%) cancer tissues (Figures S3–S13), while the somatic mutation frequency was 0.1% for breast and lung; 0.2% for head and neck and prostate; 0.5% for bladder and esophageal; and 0.9% for colorectal cancer tissues (Figures S3–S13).