Data from the TCGA database (http://xena.ucsc.edu/), (accessed on 1 September 2022) using unpaired samples of cancer and noncancerous tissues, indicated that YY1 mRNA levels are significantly upregulated in various types of malignancies, including bile duct, esophageal, head and neck, lung, and liver cancers (Figure 7A). The gene discussed is YY1; the disease is cancer.