Therefore, we analyzed the response to X-ray exposure (0–8 Gy) of chronically hypoxic (48 h exposure to 1% O2) H358 cells—a p53-null human NSCLC cell line—compared to normoxic controls, considering cell survival, cell cycle progression, DNA double-strand break (DSB) induction and repair, and interleukin (IL-6 and IL-8) production (Figure 1a,b). Here, TP53 is linked to non-small cell lung carcinoma.