It is well established that tumor hypoxia may lead to enhanced clonogenicity and “stemness” in some cells through various cellular adaptations, most commonly by increasing the nuclear accumulation of the activated hypoxia-inducible factor 1 (HIF-1), which in turn upregulates the transcription of several genes, inducing stem-cell-like properties within the tumor cells [51,52,53]. Here, HIF1A is linked to neoplasm.