The mutation (FOXRED1:694C>T) is associated with Complex I deficiency, which leads to mitochondrial dysfunction and encephalopathy [92], as well as association with Leigh syndrome and the Warburg effect, due to deficient OXPHOS, the suggestion is that the organism would tend to elevate glycolysis [93,94]. This evidence concerns the gene FOXRED1 and hyperinsulinemic hypoglycemia, familial, 4.