Figure 1C shows the mutation rate per gene, where silent mutations have already been removed, mainly to show potentially pathogenic genes in our cohort and where other potential genes could be identified (PKLR, LDHC, GPD1, FBP1, and COX10). Figure 2 shows the characterization of variants per sample, highlighting the estimate of tumor mutation burden (TMB), in which sample “TCGA-AN-A046” presents the highest rate, presenting 26 variants in glycolysis and OXPHOS genes. The gene discussed is COX10; the disease is neoplasm.