Mutations in PFKP and PFKM are related to basal glycolysis, glycogen storage diseases, and metastatic progression, and its loss decreased tumor proliferation and progression in cancer, which suggests pathogenic variants in these genes could be associated with BC, especially since PFKM had a variant with a VAF above 0.5, potentially indicating its key role in initial tumor formation, which deserves attention [36,37,38,50]. The gene discussed is PFKM; the disease is breast cancer.