Together with the distribution of the NOTCH2*1A01/*1a4 combination studied in detail in this work (Figure 4), the local frequencies of NOTCH2*1a4v1 and *1a4v2 (Figure 3c,d) resemble the differences in CLL incidence between persons of European descent compared to East Asians [1,2,3], making these recent NOTCH2*1a4 subvariants additional candidates for hereditary and geographical aspects of CLL. Here, NOTCH2 is linked to B-cell chronic lymphocytic leukemia.