NOTCH2 and B-cell chronic lymphocytic leukemia: Nineteen Spanish CLL cases (37%) are heterozygous (n = 18) or homozygous (n = 1) for the recent NOTCH2*1a4 subvariant 2 (*1a4v2), whose two common SNVs are located within the corresponding NOTCH2ΔNRR deleted region in intron 22 (for rs4659248) and intron23 (for rs72697235), respectively (Figure 3b,c, and Table S3).