Fourteen Spanish CLL cases (27%) are heterozygous (n = 12) or homozygous (n = 2) for the recent NOTCH2*1a4 subvariant 1 (*1a4v1), whose two common SNVs are located on the one hand in the corresponding NOTCH2ΔNRR minimal deleted region (MDR) in intron 24 (for rs17258579) and on the other hand in the intergenic region between NOTCH2 and the testis-specific expressed ADAM30 (for rs115764389) gene (Figure 3b,c and Table S3). This evidence concerns the gene NOTCH2 and B-cell chronic lymphocytic leukemia.