The expected DNA fragments after a PsiI/HpyCH4IV double-digestion in a case homozygous for NOTCH2*1a4 compared to the pattern of a cases heterozygous for NOTCH2*1A01 and NOTCH2*1a4 (Figure 6a) together with a proof-of-concept RFLP with four healthy donors and 9 CLL samples (Figure 6b) are shown in Figure 6. Here, NOTCH2 is linked to B-cell chronic lymphocytic leukemia.