In cholangiocarcinoma, HOTAIR suppresses autophagy by modulating the MIR204-5p–HMGB1 (high mobility group box 1) axis [182], while it regulates autophagy through the MIR20B-5p–ATG7 pathway in hepatic ischemia-reperfusion injury [196]. The gene discussed is HMGB1; the disease is ischemia reperfusion injury.