For instance, in males, the directions of the associations with PA of the same alleles of rs10245704 (DNAJB6/LOC101927914 locus on chr.7) and rs1999224 (TOR2A/SH2D3C/STXBP1-/CDK9/FPGS/ENG gene cluster on chr.9) were replicated in the UK cohort, while associations of the same alleles with AD were of opposite directions in the UK and US meta-samples. The gene discussed is STXBP1; the disease is Alzheimer disease.