The Wald test (see Table 2 and Table S1) demonstrated at least a marginally significant difference between males and females in the associations of all these SNPs with AD and for four SNPs (mapped to SLC25A3P1/DMRTB1/GLIS1, OPRM1/IPCEF1, FAM167A/BLK/LINC00208, and SBK3 gene clusters) with PA. The gene discussed is GLIS1; the disease is Alzheimer disease.