The benefits of PA in cognition include increased cerebral blood flow, angiogenesis, neurogenesis, neurotransmission, synaptogenesis, and synaptic strength and plasticity; the imparting of substantial neuroprotection; enhanced levels of myokines, growth, and neurotrophic factors (Irisin, Cathepsin B, BDNF, IGF-1, LIF, L-Lactate, NGF, GDNF, VEGF); and decreased toxic Aβ and tau (key biomarkers of AD pathology) [14,15,16,17,18,19,20,21,22]. The gene discussed is MAPT; the disease is Alzheimer disease.