Several somatic mutations in genes were central to the involvement of CLL or in B-cell signaling pathways, e.g., ATM (11:108251037 G>A and 11:108365085 C>G), BIRC3 (11:102331211 A>AG and 11:102336973 CAAAG>C), NOTCH1 (9:136496196 CAG>C), PTPN11 (12:112486553 G>A), SF3B1 (2:197402767 C>G), SPEN (1:15930057 GAGGATCC>G), TP53 (17:7675088 C>T), and UBR5 (8:102296933 TACA>T), and were confirmed at the transcriptional level. Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.