The impact of EBV infection on oral cancer development has also been studied; for example, EBNA1 from EBV infection can lead to p53 inactivation [15] and LMP1 can upregulate EGFR transcription and promote the malignant transformation of epithelial cells by suppressing cancer cell apoptosis [16]. This evidence concerns the gene EGFR and Epstein-Barr virus infection.