The present study showed that VWA8-AS1 interacts with several proteins critical for cellular regulation, such as CNOT4, EIF4G2, ELAVL4, HNRNPK, HNRNP, IGF2BP1, IGF2BP2, KHDRBS3, SNRNP70, RC3H1, SRSF1, SRSF9, and FOXA1, which are overexpressed in various cancers and involved in cell proliferation and tumorigenesis. This evidence concerns the gene SRSF1 and cancer.