The present study showed that VWA8-AS1 interacts with several proteins critical for cellular regulation, such as CNOT4, EIF4G2, ELAVL4, HNRNPK, HNRNP, IGF2BP1, IGF2BP2, KHDRBS3, SNRNP70, RC3H1, SRSF1, SRSF9, and FOXA1, which are overexpressed in various cancers and involved in cell proliferation and tumorigenesis. The gene discussed is VWA8; the disease is cancer.